Chosen Solution

Cut the cable removing the old screen, but had one on hand just in case. Installed, didn’t work. Assumed it was defective, ordered another. Also doesn’t work. No visible damage anywhere. whats going on??

I agree with Mark’s good advice. You could also just check to make sure that the connector end of the flex is not smudged by oil residue from your fingers. This can also be enough to keep it from making contact. Clean the contact with alcohol and then try it again. If that doesn’t do it, you can always replace the home button assembly and flex. I’m sure you can find the parts here on iFixit.