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My ipad pro buttom speakers has been blocked with slime, somis there an easy way to fix it? And if I have to open for the inside will it effect the ipad “ life “ duration?

Have you tried cleaning the speaker holes at the bottom of the iPad? If that doesn’t help, you’ll need to open the iPad and most likely clean the speaker holes or replace the speaker depending on the issue. Does the speaker still play sound or is it muffled? Does the speaker not play sound at all? Need to know a little more on the current state of the iPad. No opening the iPad won’t affect the iPad’s life if done right.